Resistant hypertension is typically defined as uncontrolled blood pressure (systolic and diastolic blood pressure >140 mmHg and >90 mmHg, respectively) despite treatment with at least three ...

Arterial hypertension is a very complex disease characterized by a sustained rise in systolic and/or diastolic ... therapeutic failure is represented by resistant (or refractory) hypertension.

The investigational aldosterone synthase inhibitor lorundrostat effectively lowered 24-hour BP for adults with well-treated, ...

The technique should be used only in patients with truly resistant hypertension, defined as a sustained clinic systolic blood pressure of at least 160 mmHg (150 mmHg in Type 2 diabetes ...

The primary endpoint was the change from baseline in systolic blood pressure (SBP ... lorundrostat in patients with uncontrolled hypertension or resistant hypertension. The trial met its primary ...

Resistant hypertension is a condition in which a person ... calculated by subtracting the diastolic blood pressure from the systolic blood pressure. High pulse pressure (when the arteries are ...

This study offers hope for individuals with uncontrolled and treatment-resistant high blood pressure. Lorundrostat, a new drug that targets a hormone called aldosterone, has shown promise in ...

High levels of dietary salt are an important cause of resistant hypertension, and a low-salt diet reduces blood pressure in these patients to a greater extent than in normotensive people or those ...

Idorsia Ltd (SIX: IDIA) today announced that the US Food & Drug Administration (FDA), after having released TRYVIO from its REMS (Risk Evaluation and Mitigation Strategy) requirement (announced on ...

(NASDAQ:MLYS) released topline data from its pivotal Launch-HTN Phase 3 and pivotal Advance-HTN Phase 2 trials of lorundrostat for uncontrolled hypertension (uHTN) or resistant hypertension (rHTN).