Figure 1: The products of two genes are required to reconstitute basic telomerase activity; the RNA component, hTR, which includes the template for synthesis of telomere DNA, and the protein ...

Telomerase is a ribonucleoprotein enzyme that maintains the protective structures at the ends of eukaryotic chromosomes, called telomeres. In most human somatic cells, telomerase expression is ...

Furthermore, telomere shortening due to the inability of the DNA-replication machinery to fully replicate the ends is a critical mechanism of tumor suppression as well as a hallmark of aging.

Carol Greider and Elizabeth Blackburn identified telomerase, the enzyme that makes telomere DNA ... This experiment showed that the biochemical machinery involved in telomere replication had to be ...

The activation of telomerase in the cells of inner cells mass is a crucial step ... The G-richness and highly repetitive nature of telomeric DNA pose major challenges to the DNA replication machinery.

Having determined how telomerase is recruited ... travels to telomere to facilitate C-strand maintenance across replication cycles. Sarah Cai, a Ph.D. candidate at Rockefeller, began investigating ...