Gene Therapy - Bone regeneration in a rat cranial defect with delivery of PEI-condensed plasmid DNA encoding for bone morphogenetic protein-4 (BMP-4) Skip to main content.

A new dual delivery system designed to sequentially release BMP2 and IGF1 in microparticles in an injectable hydrogel successfully healed an 8-mm cranial defect in rats. The study design and ...

" His lab used a human periosteum cell culture model and a rat cranial defect animal model to illustrate the efficacy of this scaffold and live 3D printing method for potential clinical translation.

The experimental material accelerates bone regeneration across skull defects in rats, according to initial results by Ramille N. Shah, PhD, and colleagues of Northwestern University and University ...

After implantation into rabbit cranial defects for 12 weeks, Gyr-Tub achieved the best repairing effects by accelerating the generation of bone tissues and blood vessels.

THE treatment of defects of the cranial bones is a problem as old as cranial surgery. All types of material have been used, and the search for a completely satisfactory substance continues.

The critical size cranial defects in a rat model exhibited nearly complete bone regeneration when the mineralized scaffolds were implanted in the defect sites. Due to the superior biophysical ...

Hyperelastic bone, a new synthetic material readily produced by 3D-printing could offer a powerful new tool for reconstructing skull defects, reports a new study.

Photograph of a 3D-printed Hyperelastic Bone human spinal section Adam E. Jakus, PhD A 3D-printed synthetic bone has been used to fix the spine and skull of a rat and a monkey. The 'hyperelastic ...

Birth defects of the face and skull are relatively common in humans, striking one in 500 to 1,000 babies. Defects can include cleft lip or palate, congenitally missing teeth and severe ...