Receptor activator of nuclear factor kappa B ligand (RANKL) stimulation induces the differentiation of macrophages into osteoclasts. Further, bone morphogenetic protein (BMP) and transforming ...

The researchers have previously reported that IL-3 inhibits osteoclast differentiation induced by receptor activator of nuclear factor-κB ligand (RANKL) or TNF, but the role of this interleukin ...

via a direct action on osteoclast precursors, but simultaneously stimulates osteoclastogenesis (and hence bone resorption) via an indirect pathway—IFN-γ stimulates antigen-dependent T-cell ...

Furthermore, the anti-cANGPTL4 antibody was shown to mitigate RANKL-induced osteoclastogenesis ... thereby suppressing osteoclast activation. "Our work not only identifies a potential valuable ...