Complementary discoveries have the potential to enhance treatment options for antibiotic-resistant infections. Researchers at ...

导读近日，华人学者张锋再获大奖。此次获得的奖项是美国科学技术领域的最高荣誉。MIT理学院院长表示，“张锋是CRISPR技术领域的杰出研究者之一，该技术加速了科学与工程的进步，融合了创业精神与科学发现。” 林 岩 | 撰文01张锋再获大奖 ...

CRISPR-Cas系统是一种广泛应用的基因编辑工具，该系统通过引导RNA（gRNA）引导Cas蛋白识别并切割靶标DNA。近年来，随着生物信息学和生物化学研究的深入，CRISPR系统的多样性得到了极大扩展，尤其是在第V型家族中，这类系统依赖于高度保守的RuvC核酸酶结构域来 ...

1 CRISPR-Cas systems utilize RNA guides to direct Cas proteins to specific DNA sequences, where the Cas protein cleaves the DNA. This ability to precisely target and cut DNA is the foundation for ...

2018 saw a breakthrough in the field of RNA interference (RNAi), when the US FDA approved the first drug using this gene-silencing mechanism. Five years and five more approved drugs later, RNAi ...

The integration of RNAi with other technologies, such as CRISPR-Cas9 gene editing and high-throughput screening, will accelerate the discovery and development of new RNAi-based therapies for a wide ...

CRISPR sequences—short snippets of DNA from previous viruses—guide destructive enzymes towards invading bacteriophages that express the same genetic fingerprint. Scientists realized that they could ...