The RNA world hypothesis implies that coded protein synthesis evolved from a set of ribozyme catalyzed acyl-transfer reactions, including those of aminoacyl-tRNA synthetase ribozymes. We report ...

Central to this ‘RNA world’ 2, arising from the products of prebiotic chemistry 3,4,5, would have been a ribozyme catalyst able to perform templated RNA synthesis to enable replication and ...

RNA不仅是遗传信息的载体，还能作为催化分子促进化学反应。尽管目前已知的天然核酶主要催化核酸的断裂与连接反应，但“RNA世界假说（RNA world ...

Directed evolution yields an RNA polymerase ribozyme that can both replicate and transcribe RNA and thus support an RNA world. genprowebdirectory Facebook Linkedin RSS Twitter Youtube ...

The 24-3 ribozyme is thus the first ever to combine the two basic capabilities -- RNA synthesis and RNA replication -- necessary for a pre-protein, pre-DNA world of RNA life.

To make RNA, the ribozyme has to recognize the primer and the template, which base-pair with one another. Then, the ribozyme catalyzes the addition of new bases onto the primer, making an RNA ...

The "RNA world" hypothesis proposes that the earliest life on Earth may have been based on RNA—a single-stranded molecule similar in many ways to DNA—like some modern viruses. This is because ...

An RNA world paradox, the inability of folded RNAs to replicate themselves, could be resolved by ribozyme mechanism that uses triplet building blocks.

According to the RNA World hypothesis, life forms later evolved to rely on proteins and DNA because in comparison, RNA was less stable and had weaker catalytic capabilities.

The discovery of ribozymes supported the RNA World Hypothesis. The strongest argument for proving the hypothesis is perhaps that the ribosome, which assembles proteins, is itself a ribozyme.

The team’s research, published this week in the Proceedings of the National Academy of Sciences, describes a ribozyme that could create an environment in which RNA replicates itself more accurately.

The newly constructed structure in the National Botanical Gardens in Ireland, meant to symbolize the flow of information from DNA to RNA and proteins, contains a representation of the DNA double helix ...