Several well-established lipid-based in vitro DNA transfection reagents ... use as vehicles for the delivery of small interfering RNA (siRNA) into cultured cells. Ambion (now part of Life ...

Alternative splicing (AS) of pre-mRNA plays a crucial role in tissue-specific gene regulation, with disease implications due to splicing defects. Predicting and manipulating AS can therefore uncover ...

but the use of well-designed and in vitro validated guide RNA constructs is instrumental for a successful genome editing project. FINGEEC provides validation of the customer designed or commercial ...