The processing and degradation of RNA sequences is ubiquitous ... Despite the presence of multiple catalytic sites, the purified yeast exosome is almost entirely inactive. However, several ...

Here we study the Sulfolobus solfataricus archaeal Rrp4–exosome in complex with substrate ... reduced after the 3′ end of the RNA enters the catalytic barrel, thereby reducing friction during ...

Cell biology: How to keep the nucleus clean Date: February 20, 2020 Source: Aarhus University Summary: RNA turnover in the nuclei of eukaryotic cells is controlled by the RNA exosome aided by ...

A fast and simple protocol for isolating exosomal RNA from exosomes previously purified using Norgen's Exosome Purification Kits, ultracentrifugation, size-exclusion chromatography, or most other ...

This kit remains stable for two years following the date of shipment. Norgen’s Plasma/Serum Exosome and RNA Isolation Kits provide an all-in-one solution for exosome purification and sequential ...

New research from UT Southwestern suggests that RNA exosomes—the cellular machines that degrade old molecules of RNA—play a key role in the development of B cells, which are critical to the ...

the RNA exosome. In recent work, postdoctoral researcher Toomas Silla from Torben Heick Jensen's laboratory at the Department of Molecular Biology and Genetics discovered that abolished RNA ...

However, the efficient delivery and safety of short interfering RNA (siRNA) remain key challenges for its clinical application. Exosomes, as natural nanoscale extracellular vesicles, have ...

Like Codiak, many are manipulating exosomes to solve drug delivery problems for a dizzying array of therapies: small molecules, RNA therapies, proteins, viral gene therapy, and even CRISPR gene ...

New research from UT Southwestern suggests that RNA exosomes – the cellular machines that degrade old molecules of RNA – play a key role in the development of B cells, which are critical to ...

TRIBE method for identifying RNAs that interact with ribosome-binding proteins (RBPs) fuses an RBP of interest to the catalytic domain (CD) of an RNA-editing enzyme. When the RBP-CD fusion protein ...

One of the most remarkable features of rRNA is its catalytic activity. The large subunit rRNA, in particular, is responsible for the peptidyl transferase reaction, which catalyzes the formation of ...