Pyruvate is produced by glycolysis, a process in which carbohydrates are broken down to create energy. Calcium pyruvate is a popular supplement that many people use primarily for its purported ...

In humans, pyruvate kinase deficiency is the second most common erythrocyte enzyme disorder. Here, we show that pyruvate kinase deficiency provides protection against infection and replication of P.

Pyruvate kinase deficiency is a rare, hereditary, chronic condition that is associated with hemolytic anemia. In a phase 2 study, mitapivat, an oral, first-in-class activator of erythrocyte ...

A rogue protein just yanked the plug on cancer’s energy grid. And researchers at the Duke University School of Medicine just figured out how. In a new study led by cancer researcher Hui-Kuan Lin, PhD, ...

Figure 1: Proteomic screen identifies pyruvate kinase as a novel phosphotyrosine-binding protein. Figure 2: Phosphopeptide binding is specific to the M2 isoform of pyruvate kinase and involves ...

Known as the mitochondrial pyruvate carrier, this molecular machine was first proposed to exist in 1971, but it has taken until now for scientists to visualise its structure at the atomic scale ...

The researchers identified the structure of this machine, the mitochondrial pyruvate carrier (MPC), and 50 years since its discovery, have shown how it operates like the lock on a canal to ...

The paper is titled "Dietary pyruvate targets cytosolic phospholipase A2 to mitigate inflammation and obesity in mice." Pyruvate, a glycolytic metabolite, was found to inhibit adipogenic ...

Scientists have worked out the structure of this machine and shown how it operates like the lock on a canal to transport pyruvate -- a molecule generated in the body from the breakdown of sugars ...

This energy comes from glucose through a process called glycolysis, in which glucose is broken down or metabolized into a substance called pyruvate through a series of steps. When the body has ...

Pyruvate kinase deficiency is a genetic disorder affecting red blood cells that carry oxygen to all cells in the body. People with pyruvate kinase deficiency have chronic hemolytic anemia ...