A study by the team of Prof. Kodi Ravichandran (VIB-UGent Center for Inflammation Research) and colleagues found that pyroptosis, a form of programmed cell death traditionally thought to be purely ...

Pyroptosis is a proinflammatory type of cell death that is associated with gasdermin-mediated membrane hole formation, as well as cell enlargement and lysis. Pyroptosis plays an important role in ...

Caspase-1 triggers programmed necrosis called pyroptosis by gasdermin-D (GSDMD) cleavage. GSDMD-deficient cells are, however, susceptible to caspase-1-mediated cell death. Researchers at Kanazawa ...

The study shows that the Western Diet could increase the sensitivity of IBD onset through DCA-induced Gsdme-mediated pyroptosis via the DCA-S1PR2 pathway, leading to disruption of the IEC barrier.

What's usually not taught in Bio 101 is another way that cells die, a process called pyroptosis, an inflammatory and necrotic form of cell death that primarily involves cancer cells. During ...

Chimeric antigen receptor (CAR) T cells, engineered to track down and destroy cancer cells, induce pyroptosis, a messy form of cell death that causes the cells to explode, the researchers found. This ...