针对NLRP3炎症小体异常激活引发的细胞焦亡(pyroptosis)与多种炎症疾病，研究人员通过虚拟筛选与实验验证，发现新型噻唑酰胺化合物21能浓度依赖性抑制GSDMD切割、IL-1β释放及LDH渗出，其通过结合NLRP3活性位点并阻断NF-κB信号与GSDMD-NT寡聚化发挥广谱抑制作用 ...

为理解肿瘤治疗机制、克服紫杉醇耐药提供思路，助力新型抗癌策略研发。 细胞焦亡 细胞焦亡的特征 细胞焦亡（Pyroptosis），又称细胞炎性坏死，是一种促炎过程。从形态学上看，其关键特征有细胞肿胀、DNA 损伤、质膜完整性快速丧失，还能观察到核浓缩和 ...

Caspase-1 triggers programmed necrosis called pyroptosis by gasdermin-D (GSDMD) cleavage. GSDMD-deficient cells are, however, susceptible to caspase-1-mediated cell death. Researchers at Kanazawa ...

As the name suggests (pyro means fire), pyroptosis causes significant inflammation, which helps the body clear infections, but also causes severe tissue damage.

Why does pyroptosis take place? Pyroptosis is a form of programmed cell death that occurs during intracellular pathogen infection, as part of the body's antimicrobial response. Cell-surface ...

What's usually not taught in Bio 101 is another way that cells die, a process called pyroptosis, an inflammatory and necrotic form of cell death that primarily involves cancer cells. During ...

The study shows that the Western Diet could increase the sensitivity of IBD onset through DCA-induced Gsdme-mediated pyroptosis via the DCA-S1PR2 pathway, leading to disruption of the IEC barrier.

Chimeric antigen receptor (CAR) T cells, engineered to track down and destroy cancer cells, induce pyroptosis, a messy form of cell death that causes the cells to explode, the researchers found. This ...