So, pyroptosis presses both the accelerator and the brake; on the one hand inflammatory cytokines released from pyroptotic cells cause inflammation, while metabolites and oxylipins in the ...

What's usually not taught in Bio 101 is another way that cells die, a process called pyroptosis, an inflammatory and necrotic form of cell death that primarily involves cancer cells. During ...

Pyroptosis is a proinflammatory type of cell death that is associated with gasdermin-mediated membrane hole formation, as well as cell enlargement and lysis. Pyroptosis plays an important role in ...

Caspase-1 triggers programmed necrosis called pyroptosis by gasdermin-D (GSDMD) cleavage. GSDMD-deficient cells are, however, susceptible to caspase-1-mediated cell death. Researchers at Kanazawa ...

The study shows that the Western Diet could increase the sensitivity of IBD onset through DCA-induced Gsdme-mediated pyroptosis via the DCA-S1PR2 pathway, leading to disruption of the IEC barrier.

Chimeric antigen receptor (CAR) T cells, engineered to track down and destroy cancer cells, induce pyroptosis, a messy form of cell death that causes the cells to explode, the researchers found. This ...