这篇综述聚焦非编码 RNA（ncRNAs），它作为基因表达的关键调控因子，在细胞焦亡（Pyroptosis）调节中意义重大，且与多种疾病密切相关。文章系统梳理了 ncRNAs 在癌症、传染病等疾病中的分子机制和应用，探索其作为诊断标志物和治疗靶点的潜力，为相关疾病精准 ...

细胞焦亡（Pyroptosis）是近年新发现的细胞死亡方式，它与细胞凋亡不同，是一种由炎症介导的程序性细胞死亡，具有独特的形态学和分子机制特征。

2020年8月24日讯/生物谷BIOON/---2001年，Cookson等人首次使用pyroptosis来形容在巨噬细胞中发现的caspase-1依赖性细胞死亡方式。细胞 ...

针对NLRP3炎症小体异常激活引发的细胞焦亡(pyroptosis)与多种炎症疾病，研究人员通过虚拟筛选与实验验证，发现新型噻唑酰胺化合物21能浓度依赖性抑制GSDMD切割、IL-1β释放及LDH渗出，其通过结合NLRP3活性位点并阻断NF-κB信号与GSDMD-NT寡聚化发挥广谱抑制作用 ...

细胞焦亡（Pyroptosis）是一种由细胞质内病原体或内源性危险信号的检测所触发的程序性坏死类型。发生细胞焦亡的细胞会呈现出肿胀、体积增大的 ...

Why does pyroptosis take place? Pyroptosis is a form of programmed cell death that occurs during intracellular pathogen infection, as part of the body's antimicrobial response. Cell-surface ...

What's usually not taught in Bio 101 is another way that cells die, a process called pyroptosis, an inflammatory and necrotic form of cell death that primarily involves cancer cells. During ...

So, pyroptosis presses both the accelerator and the brake; on the one hand inflammatory cytokines released from pyroptotic cells cause inflammation, while metabolites and oxylipins in the ...

Caspase-1 triggers programmed necrosis called pyroptosis by gasdermin-D (GSDMD) cleavage. GSDMD-deficient cells are, however, susceptible to caspase-1-mediated cell death. Researchers at Kanazawa ...