Purine nucleoside phosphorylase (PNP) deficiency is an autosomal recessive metabolic disorder characterized by severe combined immunodeficiency and by complex neurologic symptomatology including ...

基于此，研究人员就开始寻找能够制造HIV实验性药物islatravir的方法，首先他们将目光锁定到细菌的核苷补救途径（NSP，nucleoside salvage pathway）上，该 ...

Zug, Switzerland, 8 December 2022: Laevoroc Oncology (‘Laevoroc’ or ‘the company’), a privately-owned, Swiss oncology development company, announced today the publication of key preclinical data ...

Psicofuranine (6-amino-9-β-D-psicofuranosyl purine, 2′-hydroxymethyladenosine), ¶ a purine nucleoside analogue isolated from Streptomyces hygroscopicus var. decoyious , 15 was studied for its ...

Ribavirin, the nucleoside analog 1-β-D-ribofuranosyl-1,2,4-triazole-3-carboxamide, is a broad spectrum direct antiviral agent. This drug was discovered more than 40 years ago and is efficient ...

Lumoxiti (moxetumomab pasudotox-tdfk) for injection is expected to be permanently discontinued by August 31, 2023, according to a recent communication from the Food and Drug Administration (FDA).

B. 16 nucleoside analogs validated in Calu-3 cells with the nucleoside type listed along with the EC50, ... they identified a subset of pyrimidine and purine biosynthesis inhibitors.

Plasmodium falciparum Parasites Are Killed by a Transition State Analogue of Purine Nucleoside Phosphorylase in a Primate Animal Model. PLoS ONE, 2011; 6 (11): e26916 DOI: 10.1371/journal.pone.0026916 ...

More information: Cell-surface SLC nucleoside transporters and purine levels modulate BRD4-dependent chromatin states, Nature Metabolism (2021). DOI: 10.1038/s42255-021-00386-8.

The study "Cell-surface SLC nucleoside transporters and purine levels modulate BRD4-dependent 2 chromatin states" was published in Nature Metabolism on May 10, 2021, DOI: 10.1038/s42255-021-00386-8.