Illustration of a diPUFA phospholipid, a type of lipid with two polyunsaturated fatty acyl ... a key driver of a form of cell death known as ferroptosis.

Columbia researchers have found that a rare type of lipid is a key driver of ferroptosis, a form of cell death discovered by ...

Various molecular pathways, such as glutathione peroxidase 4 (GPX4) inhibition, iron metabolism deregulation, and polyunsaturated fatty acid metabolism, converge to regulate ferroptosis.