A shared interest in the biology of aging brought a chemist, a geneticist and a biologist together to found Proteostasis Therapeutics. In 2006, chemist Jeffery Kelly from The Scripps Research ...

We aim to define molecular functions of cellular factors that facilitate protein homeostasis within the endoplasmic reticulum as well as to uncover small molecules that modulate proteostasis as ...

Herantis is capitalising on the power of the natural protein Cerebral Dopamine Neurotrophic Factor (CDNF) to restore proteostasis and slow, stop, or even reverse neurodegeneration. Despite great ...

This highlights potential therapeutic strategies to restore proteostasis. The endoplasmic reticulum (ER) is the primary site of protein folding and processing. When IECs experience high secretory ...

One of the breakthroughs of this research is its identification of how the nucleolar FIB-1-NOL-56 complex influences proteostasis. Scientists observed that its suppression not only mitigated the ...

This highlights potential therapeutic strategies to restore proteostasis. The endoplasmic reticulum (ER) is the primary site ...