为探究几丁质酶 3 样蛋白 1（CHI3L1）分泌的调控机制，研究人员分析相关数据和细胞，发现外显子 8 的可变剪接影响其分泌，为蛋白调控提供新视角。 可变剪接（Alternative splicing，AS）在通过产生结构不同的异构体来调节蛋白质功能方面起着至关重要的作用。研究 ...

While the scope of the book is broad, the unifying reliance on simple chemical principles in discussing enzyme mechanism and protein folding makes it a coherent work from start to finish.

Hence this NM construct was used to perform the biophysical studies pertaining to the mechanism of amyloid fibril formation (protein-based inheritance) 3. The assembly of the NM construct produced ...

A new process that is essential to the synthesis of cellular proteins has been discovered by an international research team. The process known as splicing causes the cell's protein-making ...

Proteins are long molecules that must fold into complex three-dimensional structures to perform their cellular functions. This folding process occasionally goes awry, resulting in misfolded proteins ...

The results of this work reveal how an alternative splicing mechanism regulates an essential factor for neuronal identity.

HHMI scientists and their colleagues discover a new mechanism of protein synthesis. Ribosomes are the cell’s molecular machines, responsible for translating genetic information in messenger RNA into ...

The Hospital for Sick Children. "Newly uncovered mechanism could drive next-gen cystic fibrosis treatments." ScienceDaily. ScienceDaily, 13 March 2025. <www.sciencedaily.com / releases / 2025 / 03 / ...