One of the main goals of protein research is to establish the connections among structure, energy landscape, dynamics and function. While the pioneering efforts of Perutz and Kendrew to determine ...

When generating novel tailor-made proteins, protein engineers routinely apply the principles of 'Darwinian' evolution. However, laboratory evolution of proteins also has the potential to test ...

The energy landscape theory suggests that while evolution has sculpted the protein's energy landscape where they can fold into their optimal structures, deviations from a perfectly funneled ...