How does protein folding get started? Two extreme views have held the imagination of workers in this field. The first is that folding is hierarchic and begins by forming local backbone structures ...

Figure 1: Best fit superposition of 47 simulated annealing structures, showing the backbone and ten core residues of a seven-fold mutant designed variant of the Streptococcal protein G ß1 domain.

Nobel Prize in Chemistry highlights AI advancements in protein science, transforming structure prediction and design with ...