A major factor in the pathogenesis of prostatic hyperplasia is the continuing growth of the transition zone of the prostate due to both epithelial and stromal proliferation ... Using primary cultures ...

The growth of prostate acini from single cell implants in mice is a major breakthrough. Such results have important clinical implications, and will ultimately change the treatment paradigm for ...

supports the activity of thalidomide against prostate cancer In their work, the investigators mainly focus on the antiangiogenic properties of thalidomide; however, other forms of stromal ...

stromal-immune cell interaction can also influence the clinical response to immune-based therapeutics, as revealed by stromal remodeling following anti-PD1 treatment in cancer patients with ...

IGF and TGFβ in prostate cancer progression and the colonization of bone - By mediating the mesenchymal transition of prostate cancer cells, TGFβ influences cell adhesion to and extravasation through ...

View Full Profile. Learn about our Editorial Policies. “[It is] interesting work that further highlights the complex intercellular crosstalk between stromal cells in cancer,” said Giulia Biffi, a ...

The new therapy, developed by the pharmaceutical company Novartis, has been a breakthrough for treating prostate cancer after it has spread and grown resistant to other drugs. The FDA approval is the ...

When prostate cancer develops in the prostate gland, this usually occurs in the outer gland cells of the prostate, Cancer Research UK states. These cells are called acinar adenocarcinomas.

What are germ cell and sex cord stromal cells? Germ cells and sex cord stromal cells form when a fetus (baby) is developing. A fetus is made from a sperm cell and an egg cell. Germ cell tumors (GCTs) ...

Prostate cancer thrives by hijacking androgen signaling, fueling rapid tumor growth. Blocking this process has been effective ...

Two new drugs to treat prostate and liver cancer have ... for adults with advanced gastrointestinal stromal tumours (Gist), a rare type of cancer of the digestive system. Spesolimab (also known ...