Figure 1: Pin1 interacts with activated p53 in a phosphorylation-dependent manner. To identify the Pin1 binding sites on p53, we generated the corresponding Ser/Thr to Ala point mutants, and ...

The prolyl isomerase PIN1 has been identified as a ... Protein phosphorylation is a key cellular signalling mechanism that induces changes in protein conformation 1,2. For example, the ...

They had a homozygous start-codon mutation in the peptidyl-prolyl isomerase B gene (PPIB), which results in a lack of cyclophilin B (CyPB), the third component of the complex. The proband's ...

FG-4592 is a novel, first-in-class hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitor (PHI) that works through stabilization of HIF, a mechanism distinct from that of current anemia ...

Fu Wenguang and Prof. Fang Jing, identified a novel mechanism for the HIF prolyl hydroxylase domain protein 3 (PHD3)-dependent proline hydroxylation of cAMP responsive element binding protein ...