Structures of Notch peptides bound to FIH imply that significant ... like post-translational modifications such as prolyl hydroxylation and phosphorylation, it has different roles in different ...

By transiently increasing the level of HIF-1α, a major positive regulator of aerobic glycolysis, through blocking prolyl hydroxylases (PHDs) that negatively control HIF-1α levels, the PHD inhibitor ...