Oncogene - MEK5 overexpression is associated with metastatic prostate cancer, and stimulates proliferation, MMP-9 expression and invasion Skip to main content Thank you for visiting nature.com.

结果发现，长期抑制 mmp-9 虽减轻了星形胶质细胞增生，但同时损害了神经功能恢复并抑制了血管生成。这些结果表明脂质代谢在 mmp-9 介导的脑损伤中起着关键作用，并且 sb-3ct 有望成为针对缺血性脑卒中的靶向星形胶质细胞脂质代谢的治疗策略。

为探究特发性肾病综合征（ins）复发危险因素，研究人员开展血清基质金属蛋白酶 - 9（mmp-9）水平与 ins 复发风险关联研究。对 29 例患者回顾分析发现，基线血清 mmp-9 水平高者复发风险高（hr=5.687，95% ci：1.179–27.44），其或可作为复发预测标志物。

The promoter region of MMP-9 between −2500 and −2000 bp was found to be ... Zhi X, Feng J et al. miR-874 Inhibits cell proliferation, migration and invasion through targeting aquaporin-3 ...

MMP-9 expression was lower in co-treated MCF-7 cells relative to dandelion extract-treated cells. However, in MDA-MB-231 cells, MMP-9 expression did not significantly differ across treatment groups.

A T/N fold-increase of 5.0 was used to discriminate between high (> 5.0) and low (< or = 5.0) T/N MMP-9 expression. High T/N MMP-9 RNA expression was associated with a significantly shorter ...

MMP-2 expression was measured by reverse transcription polymerase chain reaction (RT-PCR) and Western blot. Cell proliferation, apoptosis were examined by MTT, flow cytometry, respectively.

The firm’s pipeline comprises two preclinical-stage antibodies, the MMP-9-targeting CALY-001, and CALY-002, a humanized mAb targeting IL-15, which Calypso acquired from iDD biotech in 2013.