Medivir has developed MIV-818, a prodrug which is cleaved inside the tumor cells to produce the active metabolite TRX-TP. Subsequently, TRX-TP is incorporated into DNA, causing double-strand DNA ...

The current interest in prodrugs is evident. Since 2008, the FDA has approved over 30 prodrugs, and approximately 10% of all marketed drugs worldwide can be considered prodrugs. Consequently, the ...