Mandimycin is structurally similar to the last-line-of-defense antifungal amphotericin B, another glycosylated polyene macrolide. But instead of binding to ergosterol in the fungal cell membrane as ...

By contrast, other antifungals in this class such as amphotericin B (AmB) typically have one glycosyl group. Mandimycin is part of the family of glycosylated polyene macrolides that has provided ...

The discovery of a new preclinical compound with strong antifungal activity against multidrug-resistant pathogens is ...

without the toxicity Mandimycin is a polyene macrolide within the polyene class of antifungals. Aside from polyenes, there are two other main antifungal classes: azoles and echinocandins.