Polycomb group (PcG) proteins constitute a conserved gene silencing system with widespread roles in multicellular development, stem cell biology and cancer. Recent studies suggest that PcG ...

越来越多的证据表明, Polycomb 在心脏发育中起重要的调节作用. 因此, 进一步了解其调节作用的机制, 将为解析先天性心脏病的发病机制提供有益线索. 近期来自北京大学医学部的研究人员从表观遗传的角度, 重点阐述了Polycomb蛋白复合体与心脏发育的关系.

2024 年 8 月 24 日，浙江大学 陶增 课题组与中国水稻研究所 寇艳君 课题组在国际知名期刊 Nature Communications 上在线发表了题为“ A repressive H3K36me2 reader mediates Polycomb silencing ”的研究论文，该研究以水稻稻瘟病的致病真菌 -- 稻瘟病菌为研究对象，首次在植物病原真菌中鉴定出了类似 PRC1 ...

BAHCC1 binds H3K27me3 via a conserved BAH module to mediate gene silencing and oncogenesis. Nature Genetics , 2020; DOI: 10.1038/s41588-020-00729-3 Cite This Page : ...

They repor the BAHCC1 protein is critically involved in silencing genes and acts as an integral component of the Polycomb gene-repressive pathway in mammalian cells. Advanced Search Home ...

According to Zhang, another gene group known as the Polycomb group has been intensely studied for its role in silencing Hox in organisms ranging from flies to mammals, including humans.

How silencing a gene-silencer could lead to new cancer drugs. ... New research by scientists at CU Boulder and Harvard Medical School offers an unprecedented look at how PRC2, or polycomb repressive ...

Details appeared recently in Nature, in an article titled, “Transient loss of Polycomb components induces an epigenetic cancer fate.” “[Transient] perturbation of transcriptional silencing ...

Polycomb group complex (PgC) proteins, their binding sites, and/or how they set up silencing states in development has been a feature in practically every other talk or poster, here. Not simply a ...

More information: Nobutoshi Yamaguchi et al, Arabidopsis SDG proteins mediate Polycomb removal and transcription-coupled H3K36 methylation for gene activation, eLife (2024). DOI: 10.7554/eLife ...

A model for the role of Polycomb complexes in the maintenance of XCI. ... might compensate a lack of PRC1 or PRC2 to secure a tight silencing of X-linked genes on the Xi in embryonic lineages.