Hundreds of genes are silenced by Polycomb proteins, ... EZH2 knockdown removes the H3K27me3 mark and PRC1 from a target Hox gene, and causes it to be desilenced, ...

Polycomb group(PcG)蛋白复合体于1978年在果蝇(Drosophila melanogaster)中作为同源盒基因(homeotic genes,Hox基因)的抑制因子被发现, 作为在基因沉默中发挥关键调节作用的一类复合物, 其重要性越来越引起科学界的关注.

Mount Sinai researchers have discovered that Polycomb complexes, groups of proteins that maintain gene expression patterns, are essential for proper skin development, according to a paper ...

Prostate cancer becomes fatal when associated with metastasis. In the October 10 Nature, Sooryanarayana Varambally and colleagues describe a microarray-based analysis of genes whose expression is ...

A multi-institutional study has discovered spontaneous mutations in RNF2 (RING2) gene as the underlying cause of a novel neurological disorder.

Short RNAs Are Transcribed from Repressed Polycomb Target Genes and Interact with Polycomb Repressive Complex-2. Molecular Cell , 2010; 38 (5): 675 DOI: 10.1016/j.molcel.2010.03.019 Cite This Page : ...

A multi-institutional study has discovered spontaneous mutations in RNF2 (RING2) gene as the underlying cause of a novel neurological disorder.

Historically, fly and human Polycomb proteins were considered textbook exemplars of transcriptional repressors, or proteins that silence the process by which DNA gives rise to new proteins. Now ...

NUS biologists have discovered that Hox genes are essential for the development of eyespot patterns on the wings of Bicyclus anynana butterflies. Eyespots are beautiful and important color ...

A multi-institutional study has discovered spontaneous mutations in RNF2 (RING2) gene as the underlying cause of a novel neurological disorder. This Undiagnosed Diseases Network (UDN) study was ...

Historically, fly and human Polycomb proteins were considered textbook exemplars of transcriptional repressors, or proteins that silence the process by which DNA gives rise to new proteins. Now ...