It will be important to establish whether the use of TPO-R agonists in combination with agents that minimize platelet removal, such as the monoclonal antibody to CD20, rituximab, will provide ...

Reduction in the production of this potent platelet agonist can significantly reduce platelet aggregation. However, despite all the shortcomings, aspirin remains the cornerstone of antiplatelet ...

Dr. Woulfe's research interests focus primarily on the intracellular signaling mechanisms of platelet activation and how signaling in platelets contributes to thrombosis in vivo. Agonists that extend ...

Platelets play an important role in atherothrombotic disease. The currently available antiplatelet drugs target key steps of platelet activation including thromboxane A 2 synthesis, ADP-mediated ...