Plasma cell leukemia (PCL) is a rare disease that may present de novoor secondary to plasma cell myeloma. Advanced disease and extramedullary involvement are common clinical features at presentation.
The immunologic abnormality demonstrated in multiple myeloma is considered to be the result of abnormal function of the malignant plasma cells whereby deranged protein synthesis results in the ...
The most effective means of improving host defense in myeloma may be reduction of the number of neoplastic plasma cells and levels of anomalous globulins in the serum with chemotherapy.