为探究 PIGA-CDG 不完全外显的原因，研究人员开展相关研究。他们通过全基因组测序、家系分析及果蝇实验，发现 CNTN2 是潜在修饰基因，该成果有助于寻找罕见病治疗靶点，推动相关疾病研究进展。 X 染色体上的 PIGA 基因功能缺失突变会导致磷脂酰肌醇聚糖 A 类 ...

Polymeric immunoglobulin A (pIgA) transcytosis, mediated by the polymeric immunoglobulin receptor (pIgR), is a central component of mucosal immunity and a model for regulation of polarized ...

在上午的主旨演讲中，意大利国际地贫中心的Piga教授分享了意大利国际地贫中心的经验，他表示要从小对患者进行监控。有机会终止这些并发症的发生，或者预防这些并发症的发生。 Piga说：“关于地贫的并发症，这里列举了一部分，不是全部的。这些并发症 ...

A acquired deficiency in the PIGA gene alters red blood cells. Paroxysmal nocturnal hemoglobinuria results when these altered cells replicate. Medications can stop the breakdown of red blood cells ...

Figure 1: Frequency of PigA loss upon editing with exonic and intronic gRNAs in mouse ES cells. To understand what genetic changes underlie the generation of PigA-deficient cells, we amplified a 5 ...

There are no known risk factors for PNH. This condition involves a PIGA gene named for the phosphatidylinositol glycan class A gene. But it’s not a disease that’s inherited from your parents.

Economist Professor Gustavo Piga is the first contributor in a series of Five letters from leading Italians from the fields of politics, economics, television, art and journalism. Professor Piga ...