Site-specific tyrosyl phosphorylation is a key mediator of intracellular communication and represents a rapid readout of the cell-signaling network’s response to drugs or other stimuli.

Notably, this relationship between different phosphorylation sites, which the authors dubbed interdependency, was most pronounced in the presence of the MAP kinase p38α, with other kinases more weakly ...

The researchers demonstrated the power of the method by studying protein histidine phosphorylation in Escherichia coli.They detected 2,129 phosphorylation sites, which is about 10 times as many as ...

Title: Phosphorylation at different sites of cancer-related enzyme leads to different shape changes. Author: * Send Email To: Enter the valid email address. * Add Comment To Email: Enter the comment.

“But not knowing which kinases go with which phosphorylation sites is a huge gap in knowledge,” he added. To fill that gap, Turk and his colleagues focused on how kinases recognize their targets.

The research was centered on how the modification of one spot on the tau protein is linked with the modification of many spots, called multi-site phosphorylation. Tau hyperphosphorylation is ...

They discovered that the sarbecovirus lineage nucleocapsid protein harbors a typical GID as well as a CDK1 phosphorylation site with a conserved pSPxK/R that could help phosphorylation of GSK-3.