Ser/Thr-Ala substitution of 13 sites present in Oct-1 transcriptional regulatory domain eliminated Oct-1 phosphorylation subsequent to IR exposure. Further, these substitutions prevented Oct-1 ...

Site-specific tyrosyl phosphorylation is a key mediator of intracellular communication and represents a rapid readout of the cell-signaling network’s response to drugs or other stimuli.

For instance, scientists know that phosphorylation at serine-473 activates ... and coworkers now use chemical methods to make site-specifically phosphorylated versions of Akt (Cell 2018, DOI ...

The research was centered on how the modification of one spot on the tau protein is linked with the modification of many spots, called multi-site phosphorylation. Tau hyperphosphorylation is ...

They detected 2,129 phosphorylation sites, which is about 10 times as many as seen with established analytical methods. Of those sites, 246 were phosphohistidine sites, occurring on 173 bacterial ...

and helps attach it to a specific area of a protein known as a phosphorylation site. [N]ot knowing which kinases go with which phosphorylation sites is a huge gap in knowledge. Benjamin Turk “When a ...

They discovered that the sarbecovirus lineage nucleocapsid protein harbors a typical GID as well as a CDK1 phosphorylation site with a conserved pSPxK/R that could help phosphorylation of GSK-3.

Early in Alzheimer’s disease, phospho groups modify tau at multiple sites. What controls this process? In the July 6 Science Advances, researchers led by Arne Ittner at Flinders University, Adelaide, ...