The PI3K pathway is tightly controlled by a class of PI3Ks that generate the lipid second messenger phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P 3), and the tumor suppressor PTEN ...

As key roles in cancer have been established for PI3K and PTEN — enzymes that regulate the levels of phosphatidylinositol-3,4,5-trisphosphate — compounds targeting this pathway are entering ...

In the mid 1980s we discovered a phosphatidylinositol kinase that co-purified with several oncoproteins ... and raised the exciting possibility that Type I PI kinase was in a new signaling pathway ...

Vividion Therapeutics has dosed the first subject in a Phase I trial of an oral inhibitor, VVD-159642, aimed at treating ...