这项研究的重大意义在于，它明确指出了新生儿期作为体内造血干细胞基因治疗的“黄金窗口”，并提供了概念性验证。尽管目前体内转导率和基因修正造血的程度仍低于体外转导加预处理所能达到的水平，但研究团队在三种严重遗传病小鼠模型中取得了实质性的治疗益处，足以证明 ...

No patient received donor T cell add-back by day 30. Citrate-anti-coagulated (Vacutainer; Becton Dickinson, Le Pont de Claix, France) peripheral blood (PB) was obtained from the BM donors before ...

Randomized trials have shown that the transplantation of filgrastim-mobilized peripheral-blood stem cells from HLA-identical siblings accelerates engraftment but increases the risks of acute and ...

A new video-protocol details steps to generate human induced pluripotent stem cells from cells in the peripheral blood. Stem cells are a valuable resource for medical and biological research ...

Rates of grade III/IV acute GVHD at 3 months were 3% with cyclophosphamide-cyclosporin prophylaxis and 10% with standard prophylaxis, reported David Curtis, MBBS, PhD, of Alfred H ...

Researchers can also expand PBMC populations in culture and reprogram them into induced pluripotent stem cells (iPSCs). Scientists transplant peripheral blood-derived stem cells to regenerate tissues ...

It will take you just a few hours to donate stems cells but it will save someone’s life as it is usually the last or the only resort for those suffering from blood cancer. Stem cells are ...

A stem cell transplant uses stem cells from your bloodstream, or a donor’s bloodstream. This is also called a peripheral blood stem cell transplant. A bone marrow transplant uses stem cells from your ...

HSCT involves taking healthy stem cells from bone marrow or peripheral blood, filtering them, and infusing those stem cells into the body. A pre-transplant routine is needed to condition the cells ...

Bone marrow is a spongy material that fills the bones. These stem cells develop into 3 different types of blood cells. They are: A stem cell transplant uses stem cells from the bloodstream. This is ...