Given the evidence implicating IL-17-producing DN T cells in the pathogenesis of lupus nephritis, the authors contend that antibodies against IL-23 or IL-17 should be explored for the treatment of ...

Given the uncertainties of the pathogenesis of lupus nephritis, the need to correlate specific histologic findings with treatment and outcomes, and the need to identify biomarkers that accurately ...

Conventional lupus nephritis (LN) treatment based on cyclophosphamide ... During the last 10 years, experimental studies based on different pathogenesis pathways of LN have provided an enormous ...

Since these immune complexes appear to be instrumental in the pathogenesis of lupus nephritis, one would not expect to find active renal disease in the presence of normal serum complement levels.

Lupus nephritis is one of the most serious complications of systemic lupus erythematosus (SLE). It occurs when the immune system mistakenly attacks the kidneys, leading to inflammation and possibly to ...

Lupus nephritis is a serious complication of lupus — and because it doesn’t always cause symptoms right away, it’s important to find it early. Talk to your lupus doctor about getting screened (tested) ...

The US regulator has started a review of Roche's supplemental biologics license application (BLA) for Gazyva/Gazyvaro (obinutuzumab) as a treatment for lupus nephritis, with a decision expected in ...