In a first-of-its-kind genome-wide association study (GWAS) researchers have discovered two genes, RNF144B and ENPP1, that ...

The first systematic genome-wide association study for pseudogout has identified two genes strongly associated with disease ...

Please provide your email address to receive an email when new articles are posted on . Utilization of pyrophosphate imaging to identify patients with cardiac amyloidosis has increased, although ...

The potential to prevent and treat a common type of inflammatory arthritis has been advanced thanks to a University of Otago ...

Figure 1: FPP synthesis and mevalonate pathway. In the present work, we determine a crystal structure of FPPS in complex with FPP. Intriguingly, the product is bound not to the active site, but to ...

Please provide your email address to receive an email when new articles are posted on . Among the many unanswered questions about calcium pyrophosphate deposition — formerly called “pseudogout ...

Calcium pyrophosphate deposition (CPDD) disease is characterized by the accumulation of calcium crystals in the cartilage tissues of the joints. The crystal deposits cause inflammation of the ...

Inorganic pyrophosphate accumulates extracellularly, leading to rickets or osteomalacia. Severely affected babies often die from respiratory insufficiency due to progressive chest deformity or ...

Calcium pyrophosphate dihydrate crystal deposition (CPPD) in the retro-odontoid tissue with compression of cervicomedullary junction: Analysis of 46 cases (1984–2020) with literature review ...