研究人员们巧妙地利用荧光共振能量转移原理，将PTEN蛋白改造为构象敏感的"分子探针"。通过在其N端和C端分别标记绿色荧光蛋白与淬灭蛋白 ...

在微观的细胞宇宙中，一个名为PTEN（Phosphatase and tensin homolog）的蛋白质如同精密的分子刹车，时刻调控着细胞增殖与存亡。这个仅有403个氨基酸的 ...

A new review was published in , Volume 16, on March 13, 2025, titled "Signaling pathway dysregulation in breast cancer." ...

Of primary interest was the loss of PTEN gene function, which affects almost half of mCRPC patients and can occur due to genomic deletions or rearrangements. This gene suppresses the AKT signalling ...

"ERBB2 and PTEN are a part of different signaling pathways, but we believe they have a correlation in endometrial cancer," Dunston said. "The effect of ERBB2 targeting on endometrial cancer with ...