基于此，2025年2月14日普朗克新陈代谢研究所Henning Fenselau研究团队在Science杂志发表了“Thalamic opioids from POMC satiety neurons switch on sugar appetite”揭示了 ...

为探究饱腹感状态下对糖选择性食欲的神经生物学机制，研究人员开展了关于下丘脑阿片促黑素原（POMC）神经元的研究。结果发现 POMC 神经元投射至丘脑室旁核可抑制突触后神经元，驱动饱足时糖摄入。该发现有助于减少糖摄入，对抗暴饮暴食和肥胖。 进食后 ...

2022年11月，我院代谢疾病与药物治疗研究所何金汗教授团队在国际糖尿病领域著名期刊Diabetes发表题为《MANF in POMC neurons promotes brown adipose tissue thermogenesis and protects against diet... 2022年11月，我院代谢疾病与药物治疗研究所何金汗教授团队在国际糖尿病领域著名期刊 ...

该研究发现，大脑中控制饱腹感的 POMC 神经元同时驱动了对糖的食欲，表明了所谓的“甜点胃”实际上植根于大脑。 当一顿大餐结束了，你也吃饱 ...

下丘脑弓状核（ARC）前阿黑皮素原（POMC）神经元是调控饱腹感神经环路的核心。POMC神经元在摄食状态下被激活，通过释放α-黑素细胞刺激素（α-MSH ...

该研究发现，27HC通过作用于下丘脑弓状核（The arcuate nucleus， ARH）阿黑皮素原（proopiomelanocortin ，POMC ARH ）神经元中表达的ERα抑制小电导钙离子激活 ...

下丘脑前阿片黑皮质素（POMC）神经元是饱腹感的主要调节者，因为它们通过兴奋性黑皮质素神经肽减少食物摄入。我们发现POMC神经元不仅在进食 ...

When these POMC neurons become super active, these sort of behavioral problems result and when scientists reduce their activity, it reduces the behaviors, they report in the journal Molecular ...

The study, led by Eleanor Raffan, a veterinary geneticist at the University of Cambridge, focused on a gene known as POMC, which is found in humans as well as dogs. In a previous study ...

or pro-opiomelanocortin (POMC), proprotein convertase subtilisin/kexin type 1 (PCSK1), or leptin receptor (LEPR) deficiency. “We continue to work closely with health authorities throughout the ...

Evidence-based recommendations on setmelanotide (Imcivree) for treating obesity caused by LEPR or POMC deficiency in people 6 years and over. There is a simple discount patient access scheme for ...

The mutation is in a gene called POMC, which plays a critical role in hunger and energy use. Around 25% of Labradors and 66% of flatcoated retriever dogs have the POMC mutation, which researchers ...