结果发现该轴通过激活 cAMP-PKA-CREB 信号通路促进 ESCC 转移，这为预测 ESCC 进展及靶向治疗提供新方向。 食管鳞状细胞癌（Esophageal squamous cell carcinoma，ESCC）是一种致命性极高的恶性肿瘤，5 年生存率不到 20% 。它极易发生转移和复发，就像一个 “狡猾的敌人 ...

编辑推荐：针对生长激素型垂体腺瘤(GHPA)治疗困境，厦门大学附属第一医院团队揭示PKCδ通过调控PKA/CREB/ERK信号通路影响细胞 ...

PKA直接磷酸化核CREB，这是一种与小眼相关转录因子M (MITF-M)启动子区顺式作用CRE基序相互作用的转录因子，在CREB结合蛋白(CBP)和p300的募集中起重要 ...

GP73通过激活cAMP-PKA-CREB信号通路增强肝脏的糖异生能力，使机体血糖平衡被打破，进而导致了患者糖代谢的异常。[4] GP73与糖异生的渊源 GP73是位于 ...

近日，来自中国药科大学的研究者们在Nat Commun.杂志上发表了题为“Targeting P2Y14R protects against necroptosis of intestinal epithelial cells through PKA/CREB/RIPK1 axis in ...

A single center retrospective cohort study of patients with metastatic breast cancer and leptomeningeal disease: Updated survival data and subgroup analyses by breast cancer subtype. Updated safety ...

Transcriptomic analysis of cAMP/PKA/CREB signaling in invasive lobular breast cancer. This is an ASCO Meeting Abstract from the 2024 ASCO Annual Meeting I. This abstract does not include a full text ...

BBPH, bear bile powder high dose; BBPL, bear bile powder low dose; DSS, dextran sulfate sodium; NC, normal control; 5-ASA, 5-Amino salicylic acid. Ulcerative colitis (UC) is a chronic autoimmune ...