Traditionally, the signaling lipid PIP3 has been considered the only relevant second messenger at the leading edge, but recent live cell studies by the group have revealed that normal leading edge ...

PIP3 activates the signaling protein AKT (serine/threonine kinase). AKT can affect Aβ in two ways. One is that AKT mediates the upregulation of insulin degrading enzyme, IDE, which not only breaks ...