and oncogenes such as RAS to multiple essential cellular functions. The PI3K pathway is tightly controlled by a class of PI3Ks that generate the lipid second messenger phosphatidylinositol-3,4,5 ...

BBO-10203 is an orally bioavailable small molecule with a novel mechanism of action that is designed to inhibit the physical interaction between RAS and PI3Kα, resulting in the inhibition of RAS ...