The biological significance of activation of the PI3K-Akt and the Ras-ERK pathways in V-SEA-induced transformation was analysed in the V-SEA-RAT1 and V-SEA-3T3 cell lines by employing specific ...

The following is a summary of “ER-α36 prevents high glucose-induced cellular senescence and apoptosis in renal tubular cell,” ...

The team found that resistance to this drug is associated with the hyperactivation of the cellular pathways PI3K/AKT and MEK/ERK and have explored the possibility of inhibiting these pathways as a ...

The laboratory is studying small molecules that selectively inhibit the components of RAS-RAF-MEK-ERK and PI3K-AKT-mTOR pathways. These compounds are being used as reagents to define the role of these ...

AEZS-136 is an integral part of the Company's kinase research program comprising the investigation of different compounds for single Erk inhibition, single PI3K inhibition and dual Erk/PI3K ...

Aberrant activation of the PI3K/AKT and MAPK/ERK KRAS-effector pathways occurs often in many types of cancers, and many therapeutic agents targeting components of these pathways have been developed.

Activated RAS chain reaction leads to ERK activation. *4 PI3K/AKT (AKT): This is a serine /threonine kinase associated with controlling various functions such as cell proliferation, metabolism ...

enabling simultaneous inhibition of the Raf-Mek-Erk and the PI3K-Akt signaling cascades. AEZS-136 was discovered using the Company's proprietary compound library and high throughput screening ...