2005; Xie and Bikle, 2007). Our present analysis aims to determine how E-cadh homophilic interaction contributes to PI3K/AKT activation in EOCs. We observed in two ovarian carcinoma cell lines ...

BMPER attenuated PI3K/AKT signaling and suppressed BMP4-driven smooth muscle activation in models of PAH. BMPER overexpression mitigated the vascular remodeling that characterizes pulmonary arterial ...

Research Progress on Signaling Pathways of LGALS1 in Malignant Tumors. Journal of Biosciences and Medicines, 13, 142-155. doi: 10.4236/jbm.2025.136013 . Malignant tumors, commonly referred to as ...

38 Nevertheless, studies using proteomic analysis have confirmed AKT phosphorylation in FL samples, which is indicative of PI3K pathway activation. 39,40,42,43 Additional evidence for the ...

The following is a summary of “ER-α36 prevents high glucose-induced cellular senescence and apoptosis in renal tubular cell,” ...

Activation of the PI3K–Akt–mTOR pathway (Panel B) and activation of the Ras–MEK–ERK pathway (Panel C) are inhibited. In contrast, other signaling events, such as the activation of the p38 ...

Most patients with gastric cancer are diagnosed in advanced stages of the disease. Target identification and unveiling the molecular mechanisms behind it are crucial for this field.