Whatever the mechanism, activation of the PI3K pathway results ... Schematic of signalling through the phosphatidylinositol-3-kinase (PI3K)/AKT pathway. Class 1B PI3Ks consist of p110γ and ...

A groundbreaking study published in Research (2025, DOI: 10.34133/research.0545) has elucidated the molecular mechanisms by which protein phosphatase 2A (PP2A) regulates CD8+ T cell-mediated immune ...

Our laboratory is dedicated to understanding the consequences of activation of these pathways and to using this information to develop mechanism-based therapeutic strategies. The laboratory is ...