It is significant because this protein - the proliferating cell nuclear antigen (PCNA) - was previously thought to be 'undruggable'. The drug was tested on 70 different cancer cells in the lab ...

The team at the City of Hope, one of the largest cancer research and treatment organisations in the US, made the breakthrough against the proliferating cell nuclear antigen (PCNA) protein.

The protein proliferating cell nuclear antigen (PCNA) is found in all nucleus-containing cells and is essential for DNA replication, the process by which DNA copies itself during cell division and ...

A recent study published in the Cell Chemical Biology Journal described a small molecule inhibitor of proliferating cell nuclear antigen (PCNA) that selectively kills cancer cells. PCNA is a ...

PCNA is modified upon replication stress to deal with DNA damages. These findings highlight the role of ATAD5-RLC as a universal sweeper of PCNA for the termination during DNA replication and repair.

AOH1996 has been designed to target a cancerous variant of the proliferating cell nuclear antigen (PCNA), a protein that, in its mutated form, aids DNA replication and repair operations in all ...

Named after Anna Olivia Healey, a young girl born in 1996 who sadly died at just 9 years of age from neuroblastoma, AOH1996 targets a cancer-causing variant of a protein called proliferating cell ...

It targets a protein called proliferating cell nuclear antigen (PCNA), a donut-shaped structure that plays a key role in cell division, which could lead to a new class of cancer treatments.

However, the cancer-killing pill Malkas has been developing over the past two decades, AOH1996, targets a cancerous variant of PCNA, a protein that in its mutated form is critical in DNA ...