p53 is a common denominator among human cancers. How was it discovered? What are the persistent questions about its function? Aa Aa Aa It seems nearly impossible for a normal cell to become a ...

One helper in this process is the p53 protein. However, when it mutates, it can no longer fulfill its task. Until now, researchers have assumed that the process is the same with all mutation types.

Our lab has had a long-standing interest in the role and regulation of the p53 tumor suppressor. Mutations in the p53 gene (TP53) are often associated with aggressive tumor behavior and poor patient ...

但实际上，很少听到大象罹患癌症的案例。因为在大象的身体内，有一个对抗癌症的守护神。人类不管罹患任何一种癌症，都和这个基因的突变有关系。但是人类只有 这一组 基因，而大象却有 二十组 这个基因。

Figure 1: Wild-type Ad5 generates cytopathic effect in cells expressing wild-type p53 but not in cells expressing mutant p53. These data indicate that p53 has a determining role in allowing ...

FMC-220 is a first-in-class covalent activator of p53Y220Cdesigned to address potency and tolerability challenges of non-covalent approachesIn ...

New research from the IU School of Medicine found a discovery that could lead to new treatments for prostate cancer. The American Cancer Society said one in eight men will be diagnosed with prostate ...

Kymera Therapeutics Inc. has published the characterization of KT-253, a novel compound designed to degrade the murine double minute 2 (MDM2) protein, offering a promising approach for cancers ...

Frontier Medicines Corp. has announced the selection of FMC-220, a first-in-class covalent small-molecule activator of p53 Y220C designed to address potency and tolerability challenges of noncovalent ...

FMC-220 represents a groundbreaking advancement, with the potential to provide transformative benefits for patients with tumors harboring an important mutant of p53. Preclinical studies ...