来自中科院上海药物研究所，Scripps研究所等处的研究人员发表了题为“Structure of the human P2Y12 receptor in complex with an antithrombotic drug”的文章，首次揭示了关键受体：P2Y12与抗血栓药物复合物的高分辨率晶体结构，并从中发现了这一受体的特殊结构特征，有助于抗 ...

目前，被批准的P2Y12受体拮抗剂有两大类：不可逆的噻吩并吡啶类与可逆的ATP类似物。噻吩并吡啶类包括：噻氯匹定(ticlopidine)、氯吡格雷(clopidogrel ...

近日，来自同济大学的研究者们在Int. J. Biol. Sci杂志上发表了题为“Purinergic receptor P2Y12 boosts autoimmune hepatitis through hexokinase 2-dependent glycolysis in T cells ...

To explore the underlying mechanism, we focused on the P2Y12 purinergic receptor, which is selectively expressed in non-activated microglia and mediates process motility during early injury responses.

糖尿病心脏自主神经病变(DCAN)是糖尿病常见且严重的并发症。来自国内的研究人员通过靶向P2Y12受体，探究了颈上神经节(SCG)中驻留巨噬细胞与卫星胶质细胞(SGCs)的相互作用机制。研究发现，DCAN大鼠SCG中P2Y12受体、胶质纤维酸性蛋白(GFAP)、巨噬细胞标志物(CSF1R/CSF1 ...

The NHS is recommending the use of aspirin to help prevent heart attacks and strokes for those vulnerable to them. For anyone ...

MUNICH, Germany—A new analysis from the large SCAAR registry in Sweden is once again challenging the role of pretreatment with oral P2Y12 receptor antagonists in PCI patients, this time zeroing in on ...

The adenosine diphosphate receptor P2Y12, found on the surface of platelets, plays an important role in this essential mechanism. It belongs to the family of so-called G-protein-coupled receptors ...

Idorsia's P2Y12 receptor antagonist selatogrel has significantly inhibited platelet aggregation in two phase 2 trials. The primary endpoint successes in patients with stable coronary artery ...