一篇新的研究论文发表在《衰老》杂志第15卷第10期，题为“细胞衰老的关键因素包括通过p53-p16/RB-E2F-DREAM复合物抑制有丝分裂 ...

Ultraviolet (UV) radiation is a prevailing factor implicated in the etiology of KIN and SCCs as evidenced by the high frequency of UV-related mutations in both the p53 and p16 tumor suppressor ...

具体来说，增强的p53、p21、p16和SASP表达是细胞衰老的典型特征。与对照组相比，阿特拉津处理组的p53、磷酸化p53 (p-p53)、p21和p16蛋白水平显著上升。

Conversely, the fact that p16 Ink4a and p19 Arf accumulate as wild ... 13,14,15,16. Arf activates p53 by interacting directly with the product of the p53-inducible gene Mdm2 (HDM2 in humans ...

Antiandrogen Withdrawal Alone or in Combination With Ketoconazole in Androgen-Independent Prostate Cancer Patients: A Phase III Trial (CALGB 9583) Although altered expression of each of the four cell ...

“Our study enables us to envisage a global picture of genes and pathways dysregulated during senescence and provides novel evidence for involvement of p53/p16/RB-E2F-DREAM repressional targets ...

The team identified multiple targets of p53/p16-RB-E2F-DREAM that are essential for proliferation, mitotic progression, resolving DNA damage, maintaining chromatin integrity, and DNA synthesis ...

The execution of senescence is mainly by two pathways, p16/RB and p53/p21, which lead to CDK4/6 inhibition and RB activation to block cell cycle progression. While the regulation of p53/p21 ...