Assessment of the osteoclast motility was performed by using previously developed image analysis software CL-Quant 2.30 (Nikon) for tracking the morphological changes of osteoclasts from one ...

Confocal microscope image reveals distinct patterns of the actin in bone cells. Actin is a cytoskeletal protein that is important for cells to adhere to surfaces, and to move. Actin filaments are ...

Bone-destructive diseases such as osteoporosis and chronic inflammatory arthritis affect millions of people worldwide, causing pain, fractures, and decreased quality of life. These conditions ...

Osteoclasts, which digest old or damaged bone, ... (IMAGE) Tokyo University of Science. Caption. Osteoclasts, which digest old or damaged bone, are essential for bone maintenance.

Osteoclast-specific miR-214-3p knock-in mice have elevated serum exosomal miR-214-3p and reduced bone formation ... The images or other third party material in this article are included in ...

A giant osteoclast was defined as one having at least three of the following characteristics: more than eight nuclear profiles (two-dimensional images of a section taken through three-dimensional ...

There may be a new use for that urine you've been so thoughtlessly flushing. Scientists say it could be an alternate source of a valuable bone- and tooth-repair material, with a little help from a ...

Osteoporosis is characterized by the weakening of bones, making them fragile and prone to breakage. Excessive activity of 'osteoclasts' or bone-absorbing cells leads to bone loss. Targeting ...

Both systemic factors and locally acting factors induce the formation and activity of osteoclasts (Panel A). Systemic hormones such as parathyroid hormone, 1,25-dihydroxyvitamin D 3, and thyroxine ...

Bone-dissolving cells called osteoclasts are derived from a type of immune cells called macrophages. They are necessary for the maintenance and renewal of bones. But the intracellular mechanisms ...

The skeleton undergoes continuous remodeling throughout life in response to diverse environmental stimuli. Osteoclasts, which are specialized cells on the bone surface, break down old bone tissue (in ...

Osteoclasts and osteoblasts normally are in balance. But to treat diseases that result in bone loss, pharmaceutical companies are making efforts to specifically target bone-resorbing osteoclasts to ...