Assessment of the osteoclast motility was performed by using previously developed image analysis software CL-Quant 2.30 (Nikon) for tracking the morphological changes of osteoclasts from one ...

Osteoclast-specific miR-214-3p knock-in mice have elevated serum exosomal miR-214-3p and reduced bone formation ... The images or other third party material in this article are included in ...

A representative micrograph of osteoclast differentiation and activity in response to irradiation with blue light. Numerous small pits formed on the bone-like substrate in the half of the well ...

A scanning electron micrograph of ivory surface shows resorption pits where an osteoclast has resorbed the mineralized matrix. Micrograph taken by Western University research technician Tom ...

The skeleton undergoes continuous remodeling throughout life in response to diverse environmental stimuli. Osteoclasts, which are specialized cells on the bone surface, break down old bone tissue (in ...

Osteoclasts are formed through differentiation from a certain type of immune cell called macrophage, after which they acquire their new role in the maintenance of bones and joints: breaking down ...

Bone-destructive diseases such as osteoporosis and chronic inflammatory arthritis affect millions of people worldwide, causing pain, fractures, and decreased quality of life. These conditions ...

RANK ligand can act to enhance the effects of other factors produced by myeloma cells or in response to myeloma cells, such as MIP-1α and/or IL-6, to induce osteoclast formation. Understanding of the ...

RANK ligand can act to enhance the effects of other factors produced by myeloma cells or in response to myeloma cells, such as MIP-1α and/or IL-6, to induce osteoclast formation. Understanding of the ...

Now, a team of researchers in China and Australia has shown that SARS-CoV-2 infection can affect bone marrow macrophage (BMM)-to-osteoclast differentiation, which may impact the skeletal system.